Interactomes of the Top Networks/Associated Functions from IPA “Core Analysis”.

<p>Proteins clustered within the Top Networks/Associated Functions as derived from IPA algorithms are shown as members of “interactomes”. Proteins identified during this work are labeled in larger bold font, with the protein symbol in gold fill. Direct connections between/among proteins are shown in solid lines; indirect interactions are shown as dashed lines (also called “edges”). Connections between proteins identified in this proteomic screen are shown in dark blue; interactions between proteins we identified and proteins not identified in our proteomics are shown in turquoise. Protein shapes are indicative of function and that legend is shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042064#pone-0042064-g005" target="_blank"><b>Figure 5</b></a><b> A,B</b>. Each network’s score (Fisher’s exact test, -log [p values] shown; all networks were highly significant) and number of focus molecules (those which are “seeds” for generation of focal points within the network) are shown. The top 2 network terminologies are: (<b>A</b>) “Cell Morphology, Post-Translational Modification, Protein Folding”; (<b>B</b>) “Genetic Disorder, Hematological Disease, Renal and Urological Disease”;